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. 2014 Oct 1;8:116. doi: 10.3389/fncir.2014.00116

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Copyright © 2014 Grothe and Pecka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The MSO coincidence mechanism is derived from the LSO coincidence mechanism. The schematic depicts temporal relationships of EPSPs and IPSPs, (red and blue traces, respectively) during ipsi-favoring (1, gray), slightly contra-favoring (2, magenta) and strongly contra-favoring (3, green) input combinations. The left-hand and middle column illustrates processing of these synaptic inputs in the LSO for ILDs and ITDs respectively, and ITD processing in the MSO is shown in the right-hand panel. Note that the MSO integrates EPSPs and IPSPs from both the ipsi- and contralateral side, because of the additional excitatory (contralateral) and inhibitory (ipsilateral) inputs compared to the LSO. The panel in the lower row explains how conditions 1–3 affect spatial tuning functions in the respective nuclei.