Table 4.
Multivariate analysis of chronic kidney disease impact on the prevalence of cardiovascular disease
| Unadjusted model (OR; CI95%) | Model 1 (OR; CI95%) | Model 2 (OR; CI95%) | Model 3 (OR; CI95%) | |
|---|---|---|---|---|
| Glomerular filtration rate (eGFR) | ||||
| eGFR ≥ 60 mL/min/1.73 m2 | 1 | 1 | 1 | 1 |
| eGFR 45–59 mL/min/1.73 m2 | 2.07 (1.5-2.8) | 1.2 (0.9-1.7) | 1.2 (0.9-1.8) | 1.2 (0.9-1.8) |
| eGFR 30–44 mL/min/1.73 m2 | 4.6 (2.9-7.3) | 2.5 (1.5-4.1) | 2.3 (1.4-3.8) | 2.3 (1.4-3.9) |
| eGFR < 30 mL/min/1.73 m2 | 8.4 (3.6-19.9) | 4.3 (1.7-10.7) | 4.1 (1.6-10.2) | 4.1 (1.6-10.2) |
| For each unit below 60 mL/min/1.73 m2 | 1.072 (1.06-1.09) | 1.045 (1.03-1.06) | 1.042 (1.02-1.06) | 1.043 (1.02-1.06) |
| UACR | ||||
| Normoalbuminuria | 1 | 1 | 1 | 1 |
| Microlbuminuria (30–299 mg/gr) | 1.9 (1.4-2.7) | 1.8 (1.2-2.6) | 1.8 (1.3-2.7) | 1.6 (1.1-2.4) |
| Macroalbuminuria (≥300 mg/gr) | 5.0 (2.3-11.1) | 4.6 (1.9-10.9) | 4.2 (1.8-10.2) | 3.9 (1.6 -9.5) |
| For each unit above 29 mg/gr | 1.001 (0.99-1.01) | 1.001 (0.99-1.01) | 1.001 (0.99-1.01) | 1.001 (0.99-1.01) |
| UACR (normal) + GFR (normal) | 1 | 1 | 1 | 1 |
| UACR ↑ and eGFR ↓ | 3.3 (1.5-7.3) | 2.3 (1.0-5.3) | 2.4 (1.0-5.4) | 2.2 (0.9-5.2) |
GFR: estimated glomerular filtration rate. eGFR (normal): ≥ 60 mL/min/1,73 m2. eGFR↓: < 60 mL/min/1,73 m2.
UACR: Urine albumin/creatinine ratio . UACR (normal) < 30 mg/g. UACR ↑: ≥ 30 mg/g.
Normoalbuminuria: UACR < 30 mg/g. Microalbuminuria: UACR = 30–299 mg/g . Macroalbuminuria: UACR >300 mg/g.
Model 1 Adjusted for age and sex.
Model 2 Adjusted for age, sex, hypertension, dislipidaemia, tobacco and Body Mass Index.
Model 3 Adjusted for age, sex, hypertension, dislipidaemia , tobacco, Body Mass Index , HbA1c and T2DM duration.