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. 2014 Sep 29;9(9):e108578. doi: 10.1371/journal.pone.0108578

Table 1. Focus genes used in Ingenuity Pathway Analysis.

Focus genes PPROM 33 genes: ACE, ANG, AGT, CD14, COL1A1, COL4A3, COL4A4, CSF1, CSPG2,F3, FGF4, IFNGR2, IGF1, IGF1R, IL1A, IL6R, LIPC, LPL, MMP1, MMP10,NOS2A, NOS3, PLAT, PTGER1, REN, TBXAS1, TIMP2, TNFA, TNFRSF6,TNFR2, TNR, TRL1, VWF.
Focus genes sPTB 102 genes: ACE, ADRB2, AGT, AGTR1, AP3M2, CCL2, CCL8, COL1A2,COL3A1, COL4A2, COL4A3, COL4A4, COL5A1, COL5A2, CRHBP, CRHR2,CTLA4, CYP19A1, CYP2D6, DHFR, EPHX1, EPHX2, F3, FGF1, F5, F7, GNB3,HSD17B7, HSPA1B, HSPA1L, HSPA4, HSPA6, HSPG2, HTR2A, IFNG, IGF1,IL10, IL10RA, IL10RB, IL12B, IL15, IL18, IL1A, IL1B, IL1R1, IL1R2, IL1RAP,IL1RN, IL2RA, IL2RB, IL4, IL4R, IL5, IL6, IL6R, IL8, KL, LTF, MMP1, MMP10,MMP16, MMP2, MMP3, MMP8, MMP9, MTHFD1, NAT1, NFKB1, NFKBIB,NOD2, NOS3, NR3C1, OXTR, PAFAH1B1, CBY1, PGRMC1, PLA2G4A, PLAT,POMC, PON1, PON2, PTGER3, PTGS1, REN, SCNN1A, SELE, SERPINE1,SLC6A4, TBXAS1, TEX12, THBS4, THPO, TIMP2, TIMP3, TLR2, TLR7, TNFR1,TNFR2, TSHR, UGT1A1, VEGFA, VEGFC.
Focus genes common to PPROM & sPTB 16 genes: ACE, AGT, COL4A3, COL4A4, F3, IGF1, IL1A, IL6R, MMP1, MMP10,NOS3, PLAT, REN, TBXAS1, TIMP2, TNFR2
Focus genes unique to PPROM 17 genes * : ANG, CD14, COL1A1, CSF1, CSPG2, FGF4, IFNGR2, IGF1R, LIPC,LPL, NOS2A, PTGER1, TNF, TNFRSF6, TNR, TLR1, VWF.
Focus genes unique to sPTB 86 genes ** : ADRB2, AGTR1, AP3M2, CCL2, CCL8, COL1A2, COL3A1, COL4A2, COL5A1, COL5A2, CRHBP, CRHR2, CTLA4, CYP19A1, CYP2D6,DHFR, EPHX1, EPHX2, FGF1, F5, F7, GNB3, HSD17B7, HSPA1B, HSPA1L,HSPA4, HSPA6, HSPG2, HTR2A, IFNG, IL10, IL10RA, IL10RB, IL12B, IL15,IL18, IL1B, IL1R1, IL1R2, IL1RAP, IL1RN, IL2RA, IL2RB, IL4, IL4R, IL5, IL6, IL8, KL, LTF, MMP16, MMP2, MMP3, MMP8, MMP9, MTHFD1, NAT1,NFKB1, NFKBIB, NOD2, NR3C1, OXTR, PAFAH1B1, CBY1, PGRMC1,PLA2G4A, POMC, PON1, PON2, PTGER3, PTGS1, SCNN1A, SELE, SERPINE1, SLC6A4, TEX12, THBS4, THPO, TIMP3, TLR2, TLR7, TNFR1,TSHR, UGT1A1, VEGFA, VEGFC.

Focus genes are defined in the Ingenuity Pathway Analysis as the important (associated or above a cutoff) genes which interact with molecules in the Global Molecular Network.

*The only gene from the list of 17 genes unique to PPROM that was not investigated in sPTB was TNFRSF6 (Highlighted in bold). All other genes were investigated in both, sPTB and PPROM, but were positive for PPROM only.

** From this list of 86 associated genes, 44 were investigated in sPTB only, but not in PPROM. Genes (N = 42) not validated for PPROM, are highlighted in bold.