Table 2.
Pharmacokinetic parameters for methylprednisolone after i.v. and i.m. administration from non-compartmental analysis
| Parameters | Definition | i.v.
|
i.m
|
||
|---|---|---|---|---|---|
| ADX | Normal | ADX | Normal | ||
| λz (h−1) | Terminal slope | 2.14 (0.40) | 2.10 (0.40)a | 1.12 (1.02) | 0.66 (0.17)a |
| T1/2λz(h) | Terminal half-life | 0.33 (0.06) | 0.50 (0.12) | 1.1 (0.82) | 1.1 (0.28) |
| Cmax or C0 (μg/ml) | Maximum/initial concentrations | 36.2 (5.7) | 62.0 (23.4) | 4.2 (0.83) | 3.2 (1.2) |
| AUC0-∞ (μg.h/ml) | Area under the curve | 11.0 (1.6)b | 14.5 (2.1)c | 5.27 (0.82)b | 5.08 (1.141)c |
| CL (1/h/kg) | Clearance | 4.6 (0.5) | 3.5 (0.5) | — | — |
| CL/F (1/h/kg) | Apparent clearance | — | — | 9.68 (1.69) | 10.3 (2.7) |
| Vc (1/kg) | Central volume | 2.2 (0.2) | 2.6 (0.9) | — | — |
| Vc/F (1/kg) | Apparent central volume | — | — | 16.4 (13.1) | 16.9 (8.4) |
| F | Bioavailability | — | — | 0.48 (0.13) | 0.35 (0.22) |
(Values represent the mean ± SD);
a
p <0.01,
b
p <0.001,
c
p <0.01.