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. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: Biopharm Drug Dispos. 2007 Sep;28(6):263–273. doi: 10.1002/bdd.551

Table 3.

Pharmacokinetic parameters from model fittings

Parameters Definition Value CV%
kel (h−1) Elimination rate constant 5.57 28.6
Vc (ml/kg) Central volume 718.7 39.5
k12 (h−1) Distribution rate constant 3.61 50.8
k21 (h−1) Distribution rate constant 2.84 21.3
ka1 (h−1) Absorption rate constant 1.255 23.2
ka2 (h−1) Absorption rate constant 0.219 53.6
F Bioavailability 0.214 16.4
Fr Fraction absorbed by ka1 0.725 11.3
CLp (l/h/kg) Clearance 4.0 15.9
Va1 (l/kg) Injection site volume 0.02 30.6
Va2 (l/kg) Injection site volume 0.68 73.6