Figure 1.

Schematic representation of signaling pathways regulated by the 5-HT₇ receptor. Effects mediated by G_s-proteins are in the left section. Summary of the G₁₂-mediated signaling processes is shown in the right section. Abbreviations: GIRK—G-protein coupled inward rectifier potassium channel; AC—adenylyl cyclase; cAMP—cyclic adenosine monophosphate; PKA—protein kinase A; ERK—extracellular signal-regulated kinases; Akt—protein kinase B, Hsp90—heat shot shock protein 90; ERM—proteins of the ezrin-radixin-moesin family; GEF—guanine-nucleotide exchange factor (represented by the leukemia-associated RhoGEF LARG and p115Rho); nRTKs—non-receptor tyrosine kinases; AKAPs—A-kinase anchoring proteins; ZO—zona occludens proteins; SRF—serum response factor; SRE—serum response element.