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. 2014 Oct 1;5:422. doi: 10.3389/fimmu.2014.00422

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Copyright © 2014 Killick, Magee, Park, Taraktsoglou, Browne, Conlon, Nalpas, Gormley, Gordon, MacHugh and Hokamp.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Numbers of DE genes linked to at least one of the three key hub genes (IKBKE, MYC, and NFKB1) up to a certain distance in terms of edges/interactions. (A) Union of genes linked to the hubs and median average of 100,000 permutations, including 95% of the distribution. (B) Intersection of genes linked to the hubs and median average of 100,000 permutations, including 95% of the distribution.