Table 1.

Half-life values of hydrolytic deamination and ring degradation/opening at pH 7 and 100°.^[a]

Deamination	Half-life value	Ring degradation or opening	Half-life value
2,6-diaminopurine	2.1 yr	Thymine	56 yr
Adenine	1 yr	Uracil	12 yr
Guanine	0.8 yr	Xanthine	146 days
2,4-Diaminopyrimidine	42 days	Hypoxanthine	12 days
N4-Methylcytosine	38 days	5,6-Dihydrouracil	9.1 hours
Isocytosine	21 days
Isoguanine	20 days
Cytosine	19 days
5-Hydroxymethylcytosine	13 days
2-Thiocytosine	11 days
5-Methylcytosine	9 days

^[a]Data obtained from references [20a,24].