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Effect of the Nef-M1 peptide (M1) and anti-CXCR4 linked Nef-M1 mab (αCXCR4/M1) on MDA-MB468, HME, MDA-MB231, and MCF7 cells, as determined by TUNEL assays. Relative to untreated cells expressing CXCR4 receptors, the Nef-M1 peptide was efficient in stimulating apoptosis of cells, as determined after 48 hr of exposure. Furthermore, for cells expressing CXCR4, there were similar levels of apoptosis following treatments with Nef-M1 or αCXCR4/M1.
