Table 5.
Genes previously described to be progesterone regulated that are down-regulated in endometrium of subjects with repeated embryo implantation failure
| UniGene ID | Gene symbol | Gene title | Up regulated in window of implantation | Down regulated in endometriosis or mifepristone | Fold change | p value |
|---|---|---|---|---|---|---|
| Hs.386793 | GPX3 | Glutathione peroxidase 3 (plasma) (GPX3), mRNA. | [25, 27, 29, 32] | 0.01 | 0.00013 | |
| Hs.458355 | C1S | Complement component 1, s subcomponent, transcript variant 1, mRNA. | [28, 29] | 0.02 | 0.00043 | |
| Hs.647023 | CLDN3 | Claudin 3 | [24] | 0.07 | 0.00086 | |
| Hs.89603 | MUC1 | Mucin 1, transmembrane, mRNA. | [25] | [4] | 0.11 | 0.00022 |
| Hs.436657 | CLU | Clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J), transcript variant 1, mRNA. | [27, 29, 31, 32] | 0.12 | 0.00086 | |
| Hs.276770 | CD52 | CD52 molecule | [7] | 0.14 | 0.00043 | |
| Hs.498173 | SMPD1 | Sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase), transcript variant 1, mRNA. | [24, 26] | 0.14 | 0.00013 | |
| Hs.523414 | LOC492304 | Putative insulin-like growth factor II associated protein, mRNA. | [27] | 0.15 | 0.00022 | |
| Hs.532325 | PAEP | Progestagen-associated endometrial protein | [24, 25, 27, 31, 32] | [39] | 0.15 | 0.00086 |
| Hs.590970 | AXL | AXL receptor tyrosine kinase | [24] | 0.15 | 0.00022 | |
| Hs.163893 | PICALM | Phosphatidylinositol binding clathrin assembly protein | [4] | 0.16 | 0.00086 | |
| Hs.525607 | TNFAIP2 | Tumor necrosis factor, alpha-induced protein 2, mRNA. | [27–29, 32] | 0.18 | 0.00043 | |
| Hs.654439 | APOE | Apolipoprotein E | [24, 29] | 0.18 | 0.00086 | |
| Hs.201978 | PTGS1 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase), transcript variant 2, mRNA. | [29] | [7] | 0.19 | 0.00013 |
| Hs.82071 | CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, mRNA. | [25] | 0.19 | 0.00086 | |
| Hs.524518 | STAT6 | Signal transducer and activator of transcription 6, interleukin-4 induced, mRNA. | [29] | 0.19 | 0.00022 | |
| Hs.478588 | BCL6 | B-cell CLL/lymphoma 6 (zinc finger protein 51), transcript variant 1, mRNA. | [25, 27, 29] | 0.20 | 0.00086 | |
| Hs.1012 | C4BPA | Complement component 4 binding protein, alpha | [24, 25, 27, 29, 31, 32] | [39] | 0.22 | 0.00043 |
| Hs.21765 | FADS3 | Fatty acid desaturase 3, mRNA. | [26] | 0.23 | 0.00043 | |
| Hs.4055 | KLF6 | Kruppel-like factor 6 | [25] | 0.23 | 0.00013 | |
| Hs.332708 | FBLN5 | Fibulin 5, mRNA. | [27, 29] | 0.23 | 0.00022 | |
| Hs.25292 | JUNB | Jun B proto-oncogene, mRNA. | [25, 26] | 0.25 | 0.00043 | |
| Hs.431048 | ABL1 | V-abl Abelson murine leukemia viral oncogene homolog 1, transcript variant b, mRNA. | [24] | 0.27 | 0.00086 | |
| Hs.190783 | HAL | Histidine ammonia-lyase | [26, 32] | 0.27 | 0.00086 | |
| Hs.513984 | FLII | Flightless I homolog (Drosophila), mRNA. | [24, 32] | 0.27 | 0.00043 | |
| Hs.643357 | ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | [29] | 0.29 | 0.00022 | |
| Hs.44227 | HPSE | Heparanase | [29] | 0.29 | 0.00086 | |
| Hs.515536 | RRAS | Related RAS viral (r-ras) oncogene homolog, mRNA. | [27] | 0.29 | 0.00013 | |
| Hs.409578 | STK38 | Serine/threonine kinase 38 | [26] | 0.29 | 0.00043 | |
| Hs.549171 | C1orf56 | Chromosome 1 open reading frame 56 | [7] | 0.29 | 0.00022 | |
| Hs.494457 | NINJ1 | Ninjurin 1, mRNA. | [26] | 0.29 | 0.00013 | |
| Hs.270291 | ACTN4 | Actinin, alpha 4 (ACTN4), mRNA. | [29] | 0.29 | 0.00086 | |
| Hs.381099 | LCP1 | Lymphocyte cytosolic protein 1 (L-plastin), mRNA. | [28, 29] | 0.31 | 0.00043 | |
| Hs.185172 | GNB2 | Guanine nucleotide binding protein (G protein), beta polypeptide 2, mRNA. | [26] | 0.31 | 0.00013 | |
| Hs.1497 | RARG | Retinoic acid receptor, gamma | [7] | 0.33 | 0.00043 | |
| Hs.474751 | MYH9 | Myosin, heavy polypeptide 9, non-muscle, mRNA. | [29] | 0.33 | 0.00043 | |
| Hs.255093 | PFKL | Phosphofructokinase, liver, transcript variant 2, mRNA. | [24] | 0.33 | 0.00086 | |
| Hs.503911 | NNMT | Nicotinamide N-methyltransferase | [25, 27] | 0.33 | 0.00043 | |
| Hs.504877 | ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta , mRNA. | [24, 26, 27, 29] | 0.33 | 0.00022 | |
| Hs.210995 | CA12 | Carbonic anhydrase XII, transcript variant 2, mRNA. | [27, 32] | 0.35 | 0.00043 | |
| Hs.520640 | ACTB | Actin, beta, mRNA. | [7] | 0.35 | 0.00086 | |
| Hs.514819 | AP2B1 | Adaptor-related protein complex 2, beta 1 subunit, mRNA. | [24] | 0.35 | 0.00013 | |
| Hs.511605 | ANXA2 | Annexin A2, transcript variant 2, mRNA. | [29] | 0.35 | 0.00086 | |
| Hs.87752 | MSN | Moesin, mRNA. | [29] | 0.35 | 0.00022 | |
| Hs.654958 | ABCF2 | ATP-binding cassette, sub-family F (GCN20), member 2 | [7] | 0.35 | 0.00013 | |
| Hs.443577 | TNFRSF21 | Tumor necrosis factor receptor superfamily, member 21 | [29] | [4] | 0.35 | 0.00086 |
| Hs.591868 | ZBTB10 | Zinc finger and BTB domain containing 10 | [4] | 0.35 | 0.00043 | |
| Hs.25348 | VAMP2 | Vesicle-associated membrane protein 2 (synaptobrevin 2) | [4] | 0.38 | 0.00086 | |
| Hs.159161 | ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha, mRNA. | [24] | [7] | 0.38 | 0.00022 |
| Hs.131269 | RARRES1 | Retinoic acid receptor responder (tazarotene induced) 1 | [27] | 0.38 | 0.00086 | |
| Hs.513915 | CLDN7 | Claudin 7, mRNA. | [25] | 0.38 | 0.00013 | |
| Hs.10326 | COPE | Coatomer protein complex, subunit epsilon, transcript variant 2, mRNA. | [24] | 0.38 | 0.00013 | |
| Hs.416024 | NRSN2 | Neurensin 2 | [7] | 0.38 | 0.00043 | |
| Hs.434248 | PLEC | Plectin | [26, 29] | [39] | 0.38 | 0.00086 |
| Hs.584854 | AVIL | Advillin | [26, 29] | 0.41 | 0.00022 | |
| Hs.183109 | MAOA | Monoamine oxidase A | [24, 25, 27, 28, 31, 32] | 0.41 | 0.00013 | |
| Hs.365405 | SELO | Selenoprotein O | [4] | 0.41 | 0.00013 | |
| Hs.645228 | KIR3DL1 | Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | [29] | 0.41 | 0.00086 | |
| Hs.528299 | HTATIP | HIV-1 Tat interacting protein, 60 kDa, transcript variant 3, mRNA. | [26] | 0.41 | 0.00043 | |
| Hs.164226 | THBS1 | Thrombospondin 1, mRNA. | [29] | 0.41 | 0.00086 | |
| Hs.647078 | CDK5 | Cyclin-dependent kinase 5 | [7] | 0.41 | 0.00043 | |
| Hs.278573 | CD59 | CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), transcript variant 2, mRNA. | [29] | 0.41 | 0.00022 | |
| Hs.515162 | CALR | Calreticulin | [7] | 0.41 | 0.00043 | |
| Hs.465744 | INSR | Insulin receptor | [26] | 0.41 | 0.00013 | |
| Hs.274256 | ELOVL7 | ELOVL family member 7, elongation of long chain fatty acids (yeast) | [4] | 0.44 | 0.00086 | |
| Hs.450230 | IGFBP3 | Insulin-like growth factor binding protein 3 | [27, 29, 32] | 0.44 | 0.00086 | |
| Hs.504687 | MYL9 | Myosin, light polypeptide 9, regulatory | [27] | 0.44 | 0.00022 | |
| Hs.446641 | ARAF | V-raf murine sarcoma 3611 viral oncogene homolog, mRNA. | [25] | 0.44 | 0.00086 | |
| Hs.2030 | THBD | Thrombomodulin | [25, 27, 29] | 0.44 | 0.00013 | |
| Hs.104672 | FILIP1L | Filamin A interacting protein 1-like | [27] | 0.44 | 0.00086 | |
| Hs.75862 | SMAD4 | SMAD family member 4 | [4] | 0.44 | 0.00022 | |
| Hs.520757 | TBXAS1 | Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A), transcript variant TXS-II, mRNA. | [29] | 0.47 | 0.00013 | |
| Hs.283741 | EXOSC5 | Exosome component 5 | [7] | 0.47 | 0.00086 | |
| Hs.174312 | TLR4 | Toll-like receptor 4, transcript variant 2, mRNA. | [29] | 0.47 | 0.00043 | |
| Hs.24601 | FBLN1 | Fibulin 1 | [31] | [7] | 0.47 | 0.00086 |
| Hs.501728 | RHOG | Ras homolog gene family, member G (rho G) | [7] | 0.47 | 0.00043 | |
| Hs.220864 | CHD2 | Chromodomain helicase DNA binding protein 2 | [4] | 0.47 | 0.00086 | |
| Hs.524809 | CLIP1 | CAP-GLY domain containing linker protein 1 | [29] | 0.47 | 0.00043 | |
| Hs.92236 | MLL4 | Myeloid/lymphoid or mixed-lineage leukemia 4 | [7] | 0.47 | 0.00086 | |
| Hs.654688 | MKL1 | Megakaryoblastic leukemia (translocation) 1 | [26] | 0.47 | 0.00043 | |
| Hs.279837 | GSTM2 | Glutathione S-transferase mu 2 (muscle) | [26] | 0.47 | 0.00086 | |
| Hs.645227 | TGFB1 | Transforming growth factor, beta 1 | [7] | 0.50 | 0.00086 | |
| Hs.149261 | RUNX1 | Runt-related transcription factor 1 | [27] | 0.50 | 0.00013 | |
| Hs.522818 | L1CAM | L1 cell adhesion molecule (hydrocephalus, stenosis of aqueduct of Sylvius 1, MASA (mental retardation, aphasia, shuffling gait and adducted thumbs) syndrome, spastic paraplegia 1) | [26] | 0.50 | 0.00043 | |
| Hs.840 | IDO1 | Indoleamine 2,3-dioxygenase 1 | [24, 25, 29] | 0.50 | 0.00086 | |
| Hs.2256 | MMP7 | Matrix metalloproteinase 7 (matrilysin, uterine) | [27] | 0.50 | 0.00043 |
Data is expressed as fold change for endometrial genes down-regulated ≥2-fold in group A vs. group B that have been shown either up-regulated during the window of implantation or down-regulated in women with endometriosis or treated with mifepristone. Bolded transcripts are decreased also in group A vs. Group C.