Table 5.
Common haplotypes estimated for the FFB/FGA/FGG cluster and association with plasma average fibrinogen levels in the NPHS-II and WH-II studies
| Haplotype | rs1800790 | rs2070011 | Freq. (%) | Effect size (β), g/L | P value | Total R2 (AIC) |
|---|---|---|---|---|---|---|
| NPHS-II | ||||||
| A1 | 1 | 1 | 45.5 | Ref. | – | – |
| A2 | 1 | 2 | 35.2 | −0.019 | 0.111 | – |
| A3 | 2 | 1 | 16.4 | 0.081 | 2.42E – 07 | – |
| A4 | 2 | 2 | 2.9 | 0.027 | 0.394 | 0.66 (−5506.520) |
| Only A3 | ||||||
| A3 | – | – | – | 0.094 | 1.32E – 18 | 1.37 (−5548.332) |
| WH-II | ||||||
| B1 | 1 | 1 | 46.6 | Ref. | – | – |
| B2 | 1 | 2 | 35.0 | −0.018 | 0.141 | – |
| B3 | 2 | 1 | 15.5 | 0.072 | 1.32E – 05 | – |
| B4 | 2 | 2 | 3.0 | 0.071 | 0.035 | 0.39 (−3813.541) |
| Only B3 | ||||||
| B3 | – | – | – | 0.081 | 8.18E – 13 | 0.68 (−3836.525) |
1, Major allele; 2, Minor allele; Freq., frequency; Effect size (β coefficients) per-allele effect adjusted for age, clinic, and smoking; AIC, Akaike’s information criterion; Only A3/B3, Non-carrier, Heterozygote, Homozygote for haplotype A3/B3