. Author manuscript; available in PMC: 2014 Oct 2.

Published in final edited form as: J Pharmacogenomics Pharmacoproteomics. 2014 Jan 25;5(1):T-001. doi: 10.4172/2153-0645.T-001

Table 6.

Predicted warfarin daily doses (mg/day) with Puerto Rican population, using our derived pharmacogenetic algorithm and IWPC algorithms as compared to the actual doses of warfarin for the therapeutic effect in patients requiring High- Doses (>7 mg/day), Intermediate-Doses (≥ 3 and ≤ 7 mg/day) or Low-Doses (<3 mg/day) in our study cohort of 131 patients at VACHS anticoagulation clinic.

Prediction Model	IWPC algorithm	Puerto Rican Algorithm
High-Doses (>7 mg/day)
MAE (mg/day) 95% CI	4.68 (5.57-3.78)	1.83 (2.64-1.03)
R² (%)	2.34	18.01
p-value	0.0525
Intermediate-Doses (≥ 3 and ≤ 7 mg/day)
MAE (mg/day) 95% CI	1.18 (1.33-1.03)	0.52 (0.61-0.42)
R² (%)	0.58	66.74
p-value	1.67×10⁻¹⁰
Low-Doses (<3 mg/day)
MAE (mg/day) 95% CI	1.92 (2.28-1.57)	0.53 (0.74-0.33)
R² (%)	1.75	50.24
p-value	0.0259