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. 2014 Sep 25;9:1021–1031. doi: 10.2147/COPD.S58258

Table 3.

Events recorded in the 30 days prior to first treatment switch or addition in patients initially prescribed LAMA monotherapya

Description, n (%) Added to LAMA monotherapy (n=497) Switched from LAMA to ICS or ICS + LABA (n=313)
Moderate exacerbation 77 (15.5) 37 (11.8)
Severe exacerbation 37 (7.4) 18 (5.8)
Any exacerbation 97 (19.5) 48 (15.3)
 Also had lower respiratory tract infection and shortness of breath 23 (4.6) 11 (3.5)
 Also had lower respiratory tract infection 49 (9.9) 22 (7.0)
 Also had shortness of breath 4 (0.8) 6 (1.9)
 Exacerbation only 21 (4.2) 9 (2.9)
All-cause hospitalization 33 (6.6) 20 (6.4)
Emphysema 22 (4.4) 5 (1.6)
Lower respiratory tract infection 84 (16.9) 43 (13.7)
Shortness of breath 61 (12.3) 33 (10.5)
 Also had lower respiratory tract infection and exacerbation 23 (4.6) 11 (3.5)
 Also had lower respiratory tract infection 2 (0.4) 0
 Also had exacerbation 4 (0.8) 6 (1.9)
 Shortness of breath only 32 (6.4) 16 (5.1)
a

Notes: Patients had not received ICS at the long-acting bronchodilator index date or during the 12-month prior history. Categories are not mutually exclusive. Note that it may be difficult to distinguish between an exacerbation and a lower respiratory tract infection in a clinical setting.

Abbreviations: ICS, inhaled corticosteroids; LABA, long-acting β2-agonist; LAMA, long-acting muscarinic antagonist.