. Author manuscript; available in PMC: 2014 Oct 2.

Published in final edited form as: J Pediatr. 2014 Jun 16;165(3):528–533.e1. doi: 10.1016/j.jpeds.2014.05.013

Table II.

PedsQL percent change from baseline over the 24-month study

	Functionality parameter

	Physical	Emotional	Social	School	Total
Intercept (LSM)	6.62	6.62	11.23	14.27	5.99
P value	.160	.136	.049	.004	.048
Slope	0.302	0.019	0.492	0.126	0.184
P value	.054	.890	.201	.598	.072

LSM, least squares mean.

To summarize the analyses of percent change in PedsQL item scores from baseline, regression analyses with a mixed model of ANOVA were performed. The intercept value (LSM) represents the change from the value under immediate release cysteamine from the prior study² with its accompanying P value for that change. The slope represents the change from that new baseline during the 24 months of the current study using DR-CYS. There was no loss of the significant changes gained in the social, school, and total function parameters and no decline in the other 2 measured parameters (physical and emotional) during the 24-month study.