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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Lancet Infect Dis. 2014 Apr 24;14(6):498–509. doi: 10.1016/S1473-3099(14)70036-2

Figure 1.

Figure 1

The spectrum of critical illness-related altered pathophysiology and its effects on drug concentrations.

Legend: CL – clearance; Vd volume of distribution; RRT – renal replacement therapy; ECMO – extracorporeal membrane oxygenation