Table 2.

Characteristics of various antibiotic dosing programs

	BestDose v1.0	ID-ODS	MWPharm	DoseMe	TCI Works	First-dose	WinAUIC	CADDy Program v4.e
PK Method	Bayesian non- parametric approach	Bayesian parametric approach	Bayesian parametric approach	Bayesian parametric approach	Bayesian parametric approach	Population PK parametric approach	Non-linear regression	Non-linear regression
Adaptive feedback?	Yes	Yes	Yes	Yes	Yes	No	No	No
Web, server or terminal based?	Terminal	Terminal and Server	Terminal and Server	Terminal and Server	Terminal and Server	Web	Terminal	Web or Server
Compatibility	Windows	Mac, Windows, Linux, Android, IOS	Windows	Mac, Windows, Linux, Android, IOS	Mac, Windows	Mac, Windows, Linux, Android, IOS	Windows	Mac, Windows, Linux, Android, IOS
Smart phone application?	No	Yes	No	Yes	No	Yes	No	No
Patient covariates in dose predictions?	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Output from program?	Doses and PK parameter estimates	Dosing regimens, PK parameter estimates and PTAs	Doses and PK parameter estimates	Doses and PK parameter estimates	Doses and PK parameter estimates	Doses	PK parameter estimates	Doses
IT support available within 24 hours? *	Yes	Yes	No	Yes	Yes	No	No	Yes
Capacity for ICU and non-ICU dosing?	Yes	Yes	Yes	Yes	Yes	No	No	No
Further information	http://www.lapk.org	http://www.optimum-dosingstrategies.org	http://www.mediware.cz/index_en.html	www.doseme.com.au	www.tciworks.info	http://www.firstdose.org/	Contact the developers (Dr J Schentag)	www.jjpreisenberger.de
Cost	Current version is free.	Free	1250 euros per license	Dependent on requirements	Free	Free	Free	Free

^*Response time often depends on the severity of the problem for the user (for non-urgent issues, responses may exceed 24 hours)

Legend – ID-ODS: Individually Designed Optimum Dosing Strategies; WinAUIC: Windows Antibiotic Utilisation Information and Consultation; PK: pharmacokinetic; RRT: renal replacement therapy; AUIC: area under the inhibitory curve; MIC: minimum inhibitory concentration; ICU: intensive care unit; IT: information technology; PTA: probability of target attainment