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. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: Toxicol Appl Pharmacol. 2012 Sep 27;265(1):19–26. doi: 10.1016/j.taap.2012.09.019

Fig. 1.

Fig. 1

Atrazine inhibits PDEs in pituitary cells in static cultures. A and B, Concentration dependence of atrazine on extracellular (A) and intracellular (B) cAMP accumulation in cells bathed in medium without IBMX. C, Correlation between intracellular and extracellular cAMP levels in atrazine-treated cells. D, The lack of effects of atrazine on extracellular cAMP accumulation in cells bathed in medium containing 1 mM IBMX. E, Concentration-dependent effect of atrazine on intracellular cAMP accumulation in cells with blocked cyclic nucleotide pump by probenecid. F, Atrazine-induced increase in extracellular cAMP accumulation in cells with forskolin-stimulated adenylyl cyclase. Data are shown as the mean ± SEM from six replicates in one of three similar experiments. * p<0.01 vs. control.