Figure 3. Structural brain abnormalities in young adult young adult PSEN1 E280A mutation carriers.

In comparison with non-carriers, young adult mutation carriers have significantly less gray matter in bilateral parietal, parieto-temporal and fusiform, right parahippocampal, left temporal and mid-cingulate regions (P<0 005, uncorrected for multiple comparisons). Statistical maps are projected onto the medial and lateral surfaces of a spatially standardized brain. Maximally significant gray matter reductions are listed in Table 2.