Table 2.

Location and magnitude of most significant functional and structural brain abnormalities in young adult PSEN1 E280A mutation carriers

		Atlas Coordinates †			P-Value # *
		X	Y	Z
hippocampal/parahippocampal locations with significantly greater activation during associative memory encoding/viewing of novel face-name pairs
hippocampus++	Right	33	−8	−19	<0.0001 (0.001)*
hippocampus++	Left	−30	−16	−13	0.001
parahippocampal gyrus++	Right	33	−33	3	0.001 (0.014)*
precuneus/posterior cingulate locations with significantly less deactivation during associative memory encoding/viewing of novel face-name pairs
precuneus++	Right	18	−57	42	0.001 (0.008)*
precuneus++	Left	−12	−66	54	0.002 (0.010)*
posterior cingulate++	Right	21	−50	17	0.002 (0.009)*
locations with significantly less gray matter
parietal+	Right	55	−18	38	0.0004 (0.009)*
parietal++	Left	−38	−75	48	0.0005
temporal++	Right	51	−27	5	0.001
fusiform gyrus++	Right	38	−61	−7	0.0008
fusiform gyrus++	Left	−36	−45	−8	0.0008
parahippocampal gyrus++	Right	28	−24	−22	0.002
frontal	Right	44	14	18	0.0006
occipital	Left	−26	−61	21	0.002
cerebellum	Left	−6	−55	−11	0.002

^†Coordinates from Talairach’s brain atlas34, such that x is the distance in millimeters to the right (+) or left (−) of midline, y is the distance anterior (+) or posterior (−) to the anterior commissure, and z is the distance above (+) or below (−) a horizontal plane through the anterior and posterior commissures.

⁺⁺Located in an AD-affected search region.

^#P-values, uncorrected for multiple comparions.

^*Findings that remained significant after correcting for multiple regional in the postulated search regions are indicated by the corrected p-values shown in parentheses.