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. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: Xenobiotica. 2011 Sep 5;41(11):972–987. doi: 10.3109/00498254.2011.598582

Figure 2.

Figure 2

Correlation between the prediction accuracy [ratio of predicted/observed (Pred/Obs)] and the observed value of human clearance (CL) for small-molecule drugs using single species allometric scaling with fixed exponent of 0.65 (the average optimal value from Figure 1). The solid horizontal line represents the identity with Pred/Obs ratio = 1 and the upper and lower dotted horizontal lines represent 2-fold above and 2-fold below the identity, respectively. Several outliers with prediction error of greater than 10 were denoted as open circles. The two dotted vertical lines represent the criteria dividing small-molecules with low (hepatic extraction ratio < 0.3), medium, and high (hepatic extraction ratio > 0.7) clearance drugs.