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Correlation between the prediction accuracy [ratio of predicted/observed (Pred/Obs)] and the observed value of human clearance (CL) for macro-molecule drugs using single species allometric scaling with fixed exponent of 0.80 (the average optimal value from Figure 1). The solid horizontal line represents the identity with Pred/Obs ratio = 1 and the upper and lower dotted horizontal lines represent 2-fold above and 2-fold below the identity, respectively.
