Table 4a.

Average-fold error (AFE) of human CL predictions using multiple species scaling: comparison of small- versus macro-molecule drugs.

		SA	ROE	MA	SA+MA
Small-molecule	Hepatic (n = 50)	3.14	2.18	2.37	2.16
	Renal (n = 19)	1.84	1.95	1.73	1.66
	Mixed (n = 12)	2.25	1.99	2.09	1.97
	All (n = 81)	2.64	2.10	2.16	2.00
Macro-molecule	(n = 36)	1.67	2.06	1.87	1.95

SA, simple allometry; ROE, exponent rule-corrected SA (exponent≥1, corrected by BRW; 0.71≤exponent<1, corrected by MLP; exponent<0.71, SA); MA, multiexponential allometry; SA+MA, exponent rule-corrected MA (exponent≥0.71, MA; exponent<0.71, SA). Hepatic: drug molecules are mainly eliminated hepatically; Renal: drug molecules are mainly eliminated renally; Mixed: drug molecules are eliminated by both hepatic and renal routes.