Table 4b.

Average-fold error (AFE) of human clearance predictions using multiple species scaling for small-molecule drugs mainly hepatically eliminated with low (< 0.3), medium (0.3–0.7), and high (> 0.7) extraction ratio.

		SA	ROE	MA	SA+MA
Small-molecule	Low (n = 27)	4.51	2.81	3.31	2.79
	Medium (n = 16)	2.46	1.59	1.47	1.55
	High (n = 7)	1.35	1.71	1.99	1.74
	All (n = 50)	3.14	2.18	2.37	2.16

SA, simple allometry; ROE, exponent rule-corrected SA (exponent≥1, corrected by BRW; 0.71≤exponent<1, corrected by MLP; exponent<0.71, SA); MA, multiexponential allometry; SA+MA, exponent rule-corrected MA (exponent≥0.71, MA; exponent<0.71, SA).