Table 3.
Pharmacokinetic parameters (mean ± SEM) for plasma buprenorphine concentrations after a single dose of 0.2 mg/kg SC SRB (n= 9) and 6 doses of 0.02 mg/kg SC buprenorphine administered every 12 h (n= 8)
| SRB | Buprenorphine | |
| Cmax (ng/mL) | 5.6 ± 3.0 | 19.6 ± 4.9 |
| Tmax (h) | 13.8 ± 3.8 | 0.28 ± 0.03 |
| AUC0-168 (ng × h/mL) | 188.9 ± 15.5 | 236.3 ± 15.9 |
| AUC/D (ng × h/mL per mg/kg) | 944.7 ± 77.5 | 1969.3 ± 115.7 |
| Cmax/D (ng/mL per mg/kg) | 27.8 ± 15.2 | 163.1 ± 40.7 |
| t1/2 (h) | 64.5 | NR |
Cmax, maximal plasma concentration; D, total dose received; NR, not reported; Tmax, time when Cmax is reached; t1/2, elimination half-life for plasma (harmonic mean).