Table 4.
Interaction of the TNFα SNPs with the IL4R and IL10 SNPs in their effect on hand OA
| n | OR | 95% CI | p-value | ||
|---|---|---|---|---|---|
| IL4R | TNFα “-1031” | 0.01 | |||
| Ser/Ser | T/T | 67/270 | 1.00 | ||
| T/C – C/C | 52/138 | 2.01 | 1.26-3.22 | ||
| Ser/Pro-Pro/Pro | T/T | 33/94 | 1.00 | ||
| T/C – C/C | 8/39 | 0.55 | 0.22-1.40 | ||
| IL4R | TNFα “-863” | 0.05 | |||
| Ser/Ser | C/C | 71/285 | 1.00 | ||
| C/A – A/A | 33/99 | 2.09 | 1.29-3.27 | ||
| Ser/Pro-Pro/Pro | C/C | 48/123 | 1.00 | ||
| C/A – A/A | 8/34 | 0.72 | 0.28-1.87 | ||
| IL10 | TNFα “-1031” | 0.007 | |||
| G/A | T/T | 55/175 | 1.00 | ||
| T/C – C/C | 20/83 | 0.80 | 0.43-1.51 | ||
| A/A-G/G | T/T | 29/120 | 1.00 | ||
| T/C – C/C | 27/66 | 2.54 | 1.45-4.47 | ||
| IL10 | TNFα “-863” | 0.02 | |||
| G/A | C/C | 56/186 | 1.00 | ||
| C/A – A/A | 19/72 | 0.94 | 0.49-1.80 | ||
| A/A-G/G | C/C | 48/198 | 1.00 | ||
| C/A – A/A | 37/85 | 2.60 | 1.46-4.62 |
Odds ratios (ORs) and 95% confidence intervals (CIs) are adjusted for age, occupation and body mass index (BMI).
SNP single nucleotide polymorphism, OA osteoarthritis, OR odds ratio, CI confidence interval.