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. 2014 Sep 25;12:61. doi: 10.1186/s12964-014-0061-y

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© Hodgson et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Decreased PSA and INPP4B expression in a patient tissue derived xenograft line, LTL-418, following castration. (A) IHC staining shows decreased PSA expression and decreased nuclear expression of AR following castration. Scale bar, 100 μm. (B-D) Quantitative PCR shows an increase in AR (B), decrease in PSA (C), and decrease in INPP4B (D) expression in LTL-418 xenografts after one (Cx1W) or three (Cx3W) weeks of castration compared to noncastrated control animals. ***P < 0.0001, two-tailed Student’s t test. (E) Survivn (BIRC5) expression was analyzed using Oncomine and the Grasso Prostate Dataset GSE35988. FC – fold change.