Table 3.
Effects of resveratrol, resveratrol-loaded fibroin nanoparticles, and unloaded fibroin nanoparticles on colonic macroscopic damage score, weight/length ratio, myeloperoxidase activity, and glutathione content, in TNBS experimental rat colitis
| Group (n=10) | Damage score (0–10) | Weight/Length (mg/cm) | MPO (mU/g tissue) | GSH (nmol/g tissue) |
|---|---|---|---|---|
| Noncolitic | 0a | 65.8±3.4a | 15.3±1.7a | 2,230±202a |
| TNBS control | 7.2±0.2b | 153.6±15.8b | 119.6±24.5b | 1,114±80b |
| FNPs (8 mg/rat) | 6.2±0.4c | 117.9±10.7c | 64.9±13.1c | 1,236±44b,c |
| RL-FNPs (1+8 mg/rat)# | 5.5±0.3c | 109.8±10.0c | 33.9±9.8d | 1,477±105c |
| Resveratrol (1 mg/rat) | 6.4±0.2b,c | 128.2±12.7b,c | 76.7±21.2b,c | 1,320±131b,c |
| Dexamethasone (0.1 mg/rat) | 5.8±0.4 c | 105.4±9.4c | 35.5±8.3d | 1,497±154c |
Notes: Data are expressed as mean ± SEM. Groups with a different letter (a–d) differ statistically (P<0.05).
#
8 mg of RL-FNPs, loaded with 1 mg of resveratol.
Abbreviations: FNP, silk fibroin nanoparticle; GSH, glutathione; MPO, myeloperoxidase; RL-FNP, resveratrol-loaded silk fibroin nanoparticle; SEM, standard error of the mean; TNBS, trinitrobenzene sulphonic acid.