Fig. 3.

COMP, GEP, ADAMTS7 and PCNA immunofluorescence in brachiocephalic plaques. A–E: Brachiocephalic sections stained fluorescence-immunohistochemically for COMP (A), GEP (B), ADAMTS7 (C), and PCNA (D,E), all represented by red colour. Green colour represents autofluorescence, except for particularly bright green fluorescence in (B), which indicates α-SMA. Sections A-D are from ApoE-deficient mice, while section E is from an ApoE and COMP deficient mouse. Arrowheads point to PCNA positive cells. Scale bar: 200 μm. F: Number of PCNA positive cells per mm² (ApoE^−/−: n = 15; ApoE/COMP^−/−: n = 15). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)