Table 2.
NCP | C0 (μg/ml) |
k0 (1/h) |
Vss (mg/kg/(μg/ml)) |
Cl ((mg/kg)/( μg/ml)/h) |
AUC (μg/ml×h) |
MRT (h) |
t1/2 (h) |
---|---|---|---|---|---|---|---|
1P | 31.7±3.7 | 0.042±0.005 | 0.06±0.007 | 0.003±0.0004 | 753.1±42.8 | 23.7±4.2 | 16.4±2.9 |
2P | 16.9±4.9 | 0.058±0.017 | 0.09±0.025 | 0.005±0.0016 | 292.4±32.1 | 17.3±5.6 | 12.0±3.9 |
Parameters used to describe this model are: C0, plasma concentration at time=0; k0, elimination rate constant; t1/2, the time required to reduce the plasma concentration to one half its initial value; V, volume of distribution; Vss, volume of distribution at steady state; Cl, systemic clearance, AUC, total area under curve; MRT, mean resident time (time for 63.2% of the administered dose to be eliminated).