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. Author manuscript; available in PMC: 2014 Dec 25.
Published in final edited form as: Nat Commun. 2014 Jun 25;5:4182. doi: 10.1038/ncomms5182

Table 2.

Pharmacokinetic parameters for NCPs in CT26 colon tumor bearing mice.*

NCP C0
(μg/ml)		 k0
(1/h)		 Vss
(mg/kg/(μg/ml))		 Cl
((mg/kg)/( μg/ml)/h)		 AUC
(μg/ml×h)		 MRT
(h)		 t1/2
(h)
1P 31.7±3.7 0.042±0.005 0.06±0.007 0.003±0.0004 753.1±42.8 23.7±4.2 16.4±2.9
2P 16.9±4.9 0.058±0.017 0.09±0.025 0.005±0.0016 292.4±32.1 17.3±5.6 12.0±3.9
*

Parameters used to describe this model are: C0, plasma concentration at time=0; k0, elimination rate constant; t1/2, the time required to reduce the plasma concentration to one half its initial value; V, volume of distribution; Vss, volume of distribution at steady state; Cl, systemic clearance, AUC, total area under curve; MRT, mean resident time (time for 63.2% of the administered dose to be eliminated).