Table 2. KIR genotypes and HLA ligand combinations in CHIV- and DENV2-infected patients, compared with healthy donors from the same Gabonese population.
Control | CHIKV+ | DENV-2+ | ||||||||
n | % | n | % | p | pn | n | % | p | pn | |
Inhibitory KIR genotypes | ||||||||||
2DL1 | 54/54 | 100 | 63/73 | 86.1 | 0.0049 | 0.0338 | 52/52 | 100 | ns | ns |
2DL2 | 35/54 | 64.8 | 44/73 | 60.3 | ns | ns | 30/52 | 57.7 | ns | ns |
2DL3 | 43/54 | 79.6 | 48/73 | 65.7 | ns | ns | 41/52 | 78.8 | ns | ns |
2DL5 | 39/54 | 72.2 | 40/73 | 54.8 | ns | ns | 31/52 | 59.6 | ns | ns |
3DL1 | 54/54 | 100 | 73/75 | 97.3 | ns | ns | 47/50 | 94.0 | ns | ns |
3DL2 | 54/54 | 100 | 68/69 | 98.5 | ns | ns | 52/52 | 100 | ns | ns |
3DL3 | 54/54 | 100 | 69/69 | 100 | ns | ns | 52/52 | 100 | ns | ns |
Activating KIR genotypes | ||||||||||
2DL4 | 54/54 | 100 | 68/73 | 93.1 | ns | ns | 51/52 | 98.0 | ns | ns |
2DS1 | 10/54 | 18.5 | 11/55 | 20.0 | ns | ns | 15/52 | 28.8 | ns | ns |
2DS2 | 31/54 | 64.8 | 18/39 | 46.1 | ns | ns | 16/41 | 39.0 | ns | ns |
2DS3 | 19/54 | 79.6 | 7/36 | 19.4 | 0.0237 | ns | 6/36 | 16.7 | ns | ns |
2DS4 | 54/54 | 100 | 70/70 | 100 | ns | ns | 48/48 | 100 | ns | ns |
2DS5 | 18/54 | 33.3 | 33/56 | 58.9 | 0.0081 | 0.0489 | 23/52 | 44.2 | ns | ns |
3DS1 | 4/54 | 7.4 | 7/66 | 10.6 | ns | ns | 6/50 | 12.0 | ns | ns |
Inhibitory KIR-HLA associations | ||||||||||
C2+ in 2DL1+ | 32/47 | 68.1 | 44/48 | 91.6 | 0.0048 | 0.0238 | 26/40 | 65.0 | ns | ns |
C1+ in 2DL2+ | 20/31 | 64.5 | 21/33 | 63.4 | ns | ns | 14/22 | 63.6 | ns | ns |
C1+ in 2DL3+ | 27/38 | 71.0 | 18/40 | 45.0 | ns | ns | 21/31 | 67.7 | ns | ns |
C1+ in 2DL2/2DL3+ | 32/47 | 68.1 | 28/51 | 54.9 | ns | ns | 26/40 | 65.0 | ns | ns |
Bw4+ in 3DL1+ | 33/47 | 70.2 | 38/55 | 69.1 | ns | ns | 22/31 | 59.5 | ns | ns |
Inhibitory KIR3DL1+-HLA-Bw4 subtype associations | ||||||||||
Bw4-80Ile+ | 22/47 | 46.8 | 38/55 | 69.1 | 0.0274 | ns | 20/37 | 54.0 | ns | ns |
Bw4-80Trn+ | 12/47 | 25.5 | 1/55 | 1.8 | 0.0005 | 0.0011 | 3/37 | 8.1 | 0.0472 | ns |
Activating KIR-HLA associations | ||||||||||
C2+ in 2DS1+ | 7/8 | 87.5 | 8/8 | 100 | ns | ns | 9/12 | 75.0 | ns | ns |
C1+ in 2DS2+ | 18/22 | 64.3 | 12/17 | 70.6 | ns | ns | 10/12 | 83.3 | ns | ns |
P: Fisher exact test; Pn: The P values of statistically significant differences were then corrected by the formula Pn = 1−(1−P)n, where n is the number of comparisons [17].