Table 3.
Adjusted ORsa (95% CIs) for ASD and residential proximity to agricultural pesticide applications (any vs. none) within prespecified buffers, by time period.b
| Pesticide, buffer radius (km) | Pregnancy | Preconception | 1st trimester | 2nd trimester | 3rd trimester |
|---|---|---|---|---|---|
| Organophosphates | |||||
| 1.25 | 1.60 (1.02, 2.51) | 1.37 (0.76, 2.50) | 1.53 (0.87, 2.68) | 1.57 (0.87, 2.83) | 1.99 (1.11, 3.56) |
| 1.5 | 1.54 (1.00, 2.38) | 1.38 (0.82, 2.31) | 1.45 (0.88, 2.41) | 1.85 (1.08, 3.15) | 2.07 (1.23, 3.50) |
| 1.75 | 1.26 (0.83, 1.92) | 1.30 (0.80, 2.13) | 1.02 (0.63, 1.65) | 1.54 (0.93, 2.55) | 1.99 (1.20, 3.30) |
| Chlorpyrifos | |||||
| 1.25 | 1.57 (0.82, 3.00) | 1.07 (0.40, 2.89) | 1.26 (0.52, 3.06) | 2.55 (0.95, 6.84) | 1.83 (0.72, 4.65) |
| 1.5 | 1.66 (0.94, 2.93) | 1.07 (0.46, 2.48) | 1.32 (0.65, 2.70) | 3.31 (1.48, 7.42) | 1.78 (0.82, 3.87) |
| 1.75 | 1.78 (1.05, 3.02) | 1.25 (0.59, 2.65) | 1.12 (0.58, 2.16) | 2.63 (1.28, 5.41) | 2.15 (1.04, 4.41) |
| Pyrethroids | |||||
| 1.25 | 1.34 (0.82, 2.20) | 1.82 (0.92, 3.60) | 1.59 (0.86, 2.96) | 1.56 (0.83, 2.94) | 1.64 (0.84, 3.19) |
| 1.5 | 1.41 (0.89, 2.25) | 1.82 (1.00, 3.31) | 1.53 (0.88, 2.67) | 1.69 (0.93, 3.06) | 1.87 (1.02, 3.43) |
| 1.75 | 1.27 (0.83, 1.96) | 1.69 (0.97, 2.95) | 1.14 (0.67, 1.91) | 1.49 (0.87, 2.58) | 1.83 (1.04, 3.23) |
| Type 2 | |||||
| 1.25 | 1.40 (0.83, 2.34) | 2.01 (0.97,4.16) | 1.64 (0.85, 3.17) | 1.29 (0.65,2.56) | 1.51 (0.75, 3.05) |
| 1.5 | 1.53 (0.94, 2.51) | 1.98 (1.06, 3.71) | 1.85 (1.01, 3.38) | 1.45 (0.78, 2.73) | 1.67 (0.87, 3.21) |
| 1.75 | 1.30 (0.82, 2.05) | 1.64 (0.92, 2.94) | 1.32 (0.76, 2.29) | 1.33 (0.75, 2.38) | 1.56 (0.86, 2.84) |
| Carbamatesc | |||||
| 1.25 | 1.37 (0.66, 2.84) | — | — | — | — |
| 1.5 | 1.80 (0.81, 3.08) | — | — | — | — |
| 1.75 | 1.43 (0.78, 2.62) | — | — | — | — |
| aMultivariate multinomial conditional logistic regression with survey weights and strata variables for matching variables. All models were adjusted for paternal education, home ownership, maternal place of birth, child race/ethnicity, maternal prenatal vitamin intake (during the 3 months before pregnancy through the first month), and year of birth. bPregnancy: conception (day 0) to the end of pregnancy; preconception: 90 days before conception; 1st trimester: 0–90 days; 2nd trimester: 91–180 days; 3rd trimester: 181 days–birth. cDue to low frequency of exposure, the cell counts were too small (< 10) to explore temporal associations, and thus are not presented here. | |||||