Table 3.
Summary of mammalian study characteristics.
| Source [source ID] | Species | Time point of outcome measurement | Outcome measure | Route of exposure | Period of exposure | PFOA dose range (mg/kg BW/day)a | No. of doses administeredb | No. of litters | Reason(s) excluded from meta-analysis |
|---|---|---|---|---|---|---|---|---|---|
| Studies used in meta-analysis | |||||||||
| Hines et al. 2009 [260] | Mouse | Birth | Weight | Gavage | GDs 1–17 | 0.01–5 | 5 | 75 | NA |
| White et al. 2009 [312] | Mouse | Birth | Weight | Gavage | GDs 8–17 | 5 | 1 | 8 | NA |
| Abbott et al. 2007 [528] | Mouse | Birth | Weight | Gavage | GDs 1–17 | 0.1–1 | 4 | 58 | NA |
| White et al. 2007 [566] | Mouse | Birth | Weight | Gavage | GDs 1–17 GDs 8–17 GDs 12–17 | 5 | 1 | 37 | NA |
| Wolf et al. 2007 [571] | Mouse | Birth | Weight | Gavage | GDs 1–17 | 3–5 | 2 | 87 | NA |
| Wolf et al. 2007 [571] | Mouse | Birth | Weight | Gavage | GDs 7–17 GDs 10–17 GDs 13–17 GDs 15–17 | 5–20 | 2 | 56 | NA |
| Lau et al. 2006 [635]c | Mouse | Birth | Weight | Gavage | GDs 1–17 | 1–20 | 5 | 103 | NA |
| White et al. 2011 [3862] | Mouse | Birth | Weight | Gavage | GDs 1–17 | 1–5 | 2 | 60 | NA |
| Studies not used in meta-analysis | |||||||||
| Hu et al. 2010 [68] | Mouse | Birth | Weight | Drinking water | GDs 6–17 | 0.05–1 | 2 | 30 | Incomparable route of exposure |
| Yahia et al. 2010 [103] | Mouse | Fetal | Weight | Gavage | GDs 0–17 | 1–10 | 3 | 29 | Incomparable time point of outcome measurement |
| Yahia et al. 2010 [103] | Mouse | Birth | Weight | Gavage | GDs 0–18 | 1–10 | 3 | 20 | Time point of birth weight measurement was not specified |
| Fenton et al. 2009 [264] | Mouse | Fetal | Weight | Gavage | GD17 | 0.1–5 | 3 | 19 | Incomparable time point of outcome measurement |
| Fenton et al. 2009 [264] | Mouse | Birth | Weight | Gavage | GD17 | 0.1–5 | 3 | 19 | Dams were exposed for only 1 day of pregnancy |
| Lau et al. 2006 [635]c | Mouse | Fetal | Weight | Gavage | GDs 1–17 | 1–40 | 6 | 183 | Incomparable time point of outcome measurement |
| Hinderliter et al. 2005 [711]d | Rat | Birth | Weight | Gavage | GDs 4–21 | 3–30 | 3 | 20 | Incomparable species |
| Staples et al. 1984 [1871] | Rat | Fetal | Weight | Gavage | GDs 6–15 | 100 | 1 | 46 | Incomparable species and time point of outcome measurement |
| Staples et al. 1984 [1871] | Rat | Fetal | Weight | Inhalation | GDs 6–15 | 0.1–25 mg/m3 | 4e | 103 | Incomparable species, route of exposure, and time point of outcome measurement |
| Staples et al. 1984 [1871] | Rat | Birth | Weight | Gavage | GDs 6–15 | 100 | 1 | 21 | Incomparable species |
| Staples et al. 1984 [1871] | Rat | Birth | Weight | Inhalation | GDs 6–15 | 0.1–25 mg/m3 | 4 | 54 | Incomparable species and route of exposure |
| Boberg et al. 2008 [3061] | Rat | Fetal | Weight | Gavage | GDs 7–20/21 | 20 | 1 | 11 | Incomparable species and time point of outcome measurement |
| Onishchenko et al. 2011 [3610] | Mouse | Birth | Weight | Food | GDs 1–20 | 0.3 | 1 | 15 | Incomparable route of exposure |
| York 2002 [5122]f | Rat | Birth | Weight | Gavage | 70 days prior to breeding throughout lactation | 1–30 | 4 | 141 | Incomparable species |
| GD, gestation day. aUnless otherwise specified; the dose range is limited to those doses for which dams were analyzed. bExcludes control groups; study used one control group unless otherwise specified. cLau (2006) is listed two times (birth weight data were included in meta-analysis; fetal data were excluded from meta-analysis). dHinderliter (2005) is a peer-reviewed publication; the author provided an industry report with detailed data (Mylchreest 2003). eIncluded three control groups. fYork (2002) is an industry report; the search also identified peer-reviewed journal publications describing findings from the report (Butenhoff et al. 2004; York et al. 2010), but these journal publications were excluded as duplicates because the report provided raw data. | |||||||||