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. Author manuscript; available in PMC: 2014 Oct 2.
Published in final edited form as: Small. 2011 Apr 20;7(10):1432–1439. doi: 10.1002/smll.201002274

Figure 1.

Figure 1

Schematic diagram depicting NDI-ATRA formation and encapsulation into the vault nanoparticle. DMPC & DMPG lipids interact with ΔApo-AI-INT to form a discoidal phospholipid bilayer nanodisk (NDI). The amphipathic helices of ΔApo-AI-INT run perpendicular to the phospholipid acyl chains in a double belt-like manner around the circumference of the nanodisk. Addition of ATRA during formation results in the drugs absorbance into the lipoprotein complex. NDI packaging into the vault nanoparticle is achieved by the vault binding domain INT. Components are not drawn to scale.