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Percent change in geometric mean of PWT from baseline by dosing arm
| Time point | Placebo | 0.25 mg/kg |
0.50 mg/kg |
0.75 mg/kg |
1.00 mg/kg |
1.25 mg/kg |
1.50 mg/kg |
1.75 mg/kg |
2.00 mg/kg |
|
|---|---|---|---|---|---|---|---|---|---|---|
| Dose 1 | n | 8 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| mean | 5.2% | −12.6% | 1.9% | −6.1% | 10.2% | 17.3% | 11.3% | 8.5% | 13.0% | |
| Dose 5 | n | 8 | 5 | 5 | 5 | 3 | 5 | 5 | 5 | 5 |
| mean | 9.6% | −21.5% | −16.0% | 4.5% | −14.7% | 8.9% | 29.3% | 7.2% | 6.5% | |
| 5-Day post | n | 8 | 5 | 4 | 4 | 3 | 5 | 5 | 5 | 5 |
| mean | 2.8% | −16.3% | −8.8% | 24.4% | −19.8% | −11.9% | 10.5% | 23.2% | −0.7% |
