Table 2.

Abbreviated list of NCCN “high-risk” factors.

NCCN “high-risk” factors‡

Area M ≥ 10 mm

Area H ≥ 6 mm

Poorly defined

Recurrence

Immunosuppression

Site of prior RT or chronic inflammatory process

Rapidly growing tumor

Neurologic symptoms

Pathology

Moderately or poorly differentiated histology

Acantholytic, adenosquamous, or desmoplastic subtypes

Depth: ≥2 mm or Clark levels IV, V

Perineural or vascular involvement

Tumor is “high-risk” if ≥1 of 12 risk factors.

M = “medium” risk: forehead, scalp, cheek, neck.

H = “high” risk: “mask areas of the face” central face, ears, periauricular, eyelids, periorbital, nose, temple, and lips.

^‡Note: The study cohort in this analysis was based on cSCCs from the head and neck only. Risk factors and specifics regarding tumors on Area L (“low” risk anatomic site: trunk and extremities), hands/feet, genitalia are not listed.