Table 4. Subgroup meta-analysis of the association between DAPK1 promoter methylation and cervical cancer.
| Group | Tumor | Control | M-H pooled OR | D+L pooled OR | Heterogeneity | ||||
| M+ | N | M+ | N | OR(95%CI) | OR(96%CI) | I2(%) | P | τ2 | |
| Total | 472 | 818 | 178 | 671 | 15.32(9.97–23.55) | 19.66(8.72–44.31) | 60.0 | 0.002 | 1.34 |
| Ethnicity | |||||||||
| Non-Caucasians | 306 | 499 | 170 | 527 | 17.88(10.29–31.07) | 19.82(8.12–48.35) | 42.6 | 0.083 | 0.70 |
| Caucasians | 166 | 319 | 8 | 144 | 12.27(6.25–24.10) | 18.22(3.35–99.03) | 75.9 | <0.001 | 3.18 |
| Method | |||||||||
| MSP | 323 | 541 | 170 | 567 | 19.10(11.11–32.84) | 21.07(8.98–49.43) | 40.3 | 0.089 | 0.67 |
| QMSP | 149 | 277 | 8 | 104 | 10.46(5.21–21.01) | 15.30(2.34–99.66) | 78.8 | <0.001 | 3.41 |
| Sample size | |||||||||
| A | 177 | 298 | 160 | 513 | 25.80(12.56–53.02) | 27.25(10.67–69.58) | 29.3 | 0.195 | 0.51 |
| B | 295 | 520 | 18 | 158 | 10.70(6.22–18.42) | 13.55(3.93–46.73) | 69.3 | 0.003 | 1.71 |
Notes: Non-Caucasians included Asians and Africans; A: The case sample size was less than 60; B: The case sample size was larger or equal to 60; M-H: the fixed effects mode; D+L: the random effects model.