Table 1.
References | Sample type | miRs deregulated | miRs selected as candidate biomarkers | |
---|---|---|---|---|
Taylor et al. (2010) [24] | 113 PCa tissues 28 normal tissues |
Large screening study | Taylor et al. 10.1016/j.ccr.2010.05.026 | |
| ||||
Volinia et al. (2006) [31] | 56 PCa tissues 7 normal tissues |
39 upregulated 6 downregulated |
Volinia et al. 10.1073/pnas.0510565103; | |
| ||||
Ambs et al. (2008) [32] | 60 microdissected tumor tissues 16 normal tissues |
21 upregulated 21 downregulated |
miR-32, miR-26a, miR-181a, miR-93, miR-196a, miR25, miR-92 and let-7i |
↑ |
| ||||
Porkka et al. (2007) [38] | 5 hormone-naïve PCa tissues 4 HRPC tissues 4 BPH tissues |
14 upregulated 37 downregulated |
PCa: miR-16, miR-99 and let-7 family | ↓ |
HRPC: miR-205, miR-100 and miR-30 | ↓ | |||
| ||||
Ozen et al. (2008) [43] | 16 PCa tissues and 10 normal tissues | 9 upregulated 76 downregulated |
Let-7, miR-30, miR-16 | ↓ |
| ||||
Martens-Uzunova et al. (2012) [44] | 102 PCa tissues and normal adjacent tissues |
54 deregulated | miR-205 | ↓ |
| ||||
Larne et al. (2013) [45] | 49 PCa tissues 25 normal tissues |
7 deregulated | miR-96-5p, miR-183-5p | ↑ |
miR-145-5, miR-221-5p | ↓ | |||
(combined in miQ score) | ||||
| ||||
Moltzahn et al. (2011) [46] | Serum samples from PCa (n = 36) and HD (n = 12) | 6 upregulated 4 downregulated |
miR-20b, miR-874, miR-1274a, miR-1207-5p, miR-93, miR-106a |
↑ |
miR-223, miR-26b, miR-30c, miR-24 |
↓ | |||
| ||||
Bryant et al. (2012) [48] | Plasma samples from PCa (n = 78) and HD (n = 28) Urine samples from PCa (n = 118) and HD (n = 17) |
12 deregulated | miR-107, miR-574-3p | ↑ |
| ||||
Srivastava et al. (2013) [49] | 40 PCa tissues and 40 normal adjacent tissues. Urine samples from PCa (n = 36) and HD (n = 12) |
2 downregulated | miR-205, miR-214 | ↓ |
| ||||
Haj-Ahmad et al. (2014) [50] | Urine samples from PCa (n = 8) BPH (n = 12) patients and HD (n = 10) |
17 deregulated (only 7 selected for further analysis) |
miR-1825 (only in PCa) | ↑ |
miR-484 (in PCa and BPH) | ↓ | |||
| ||||
Schaefer et al. (2010) [54] | 76 PCa and adjacent normal tissues |
5 upregulated 10 downregulated |
miR-96, miR-182, miR-182∗ miR-183 and miR-375 |
↑ |
miR-16, miR-31, miR-125b, miR-145, miR-149, miR-181b, miR-184, miR-205, miR-221, miR-222 |
↓ |
PCa: prostate cancer; HRPC: hormone refractory prostate cancer; BPH: benign prostatic hyperplasia; HD: healthy donors, FFPE: formalin-fixed, paraffin-embedded.