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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: J Cell Physiol. 2015 Jan;230(1):131–139. doi: 10.1002/jcp.24689

Figure 4. Treatment with [lapatinib + sorafenib] radiosensitizes GBM cells.

Figure 4

GBM5 and GBM12 cells were plated as single cells in sextuplicate. Twelve h after plating cells were treated with vehicle (DMSO), sorafenib (2 μM; 4 μM), lapatinib (1 μM; 2 μM) or the drugs in combination as indicated. Thirty min after drug treatment cells were irradiated (2 Gy) or mock exposed (time out of incubator ~20 min). The media was replaced after 12h with drug free media and colonies permitted to form over the following 10 days. Colonies were fixed, stained and counted (n = 3 +/− SEM). # p < 0.05 less than corresponding value in unirradiated cells.