Table 1. LRIG mutations in human malignancy.

LRIG mutations identified in human tumors which are predicted to have a high functional impact. Mutations collated at cbioportal.org and functional impact according to Mutation Assessor, also available at cbioportal.org.

LRIG1	LRIG2	LRIG3
N102I, Cutaneous Melanoma, LRRs	N297S, Lung Adenocarcinoma, LRRs	N585Y, Hepatocellular Carcinoma, Ig-like
L104S, Endometrial Carcinoma, LRRs	N584D, Stomach Adenocarcinoma, Ig-like	P726R, Bladder Urothelial Carcinoma, Ig-like
L146R, Stomach Adenocarcinoma, LRRs	S591Y, Endometrial Carcinoma, Ig-like
N198H, Endometrial Carcinoma, LRRs	C623Y, Cutaneous Melanoma, Ig-like
L213P, Stomach Adenocarcinoma, LRRs	P723T, Pancreatic Adenocarcinoma, Ig-like
L389P, Lung squamous cell carcinoma, LRRs
L432F, Cutaneous Melanoma, LRRs
V595M, Endometrial Carcinoma, Ig-like
P626Q, Lung Adenocarcinoma, Ig-like
G718R, Cutaneous Melanoma, Ig-like
G770D, Colorectal, Ig-like