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. 1995 May 23;92(11):4937–4941. doi: 10.1073/pnas.92.11.4937

Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.

Y Sohma 1, H Sasano 1, R Shiga 1, S Saeki 1, T Suzuki 1, H Nagura 1, M Nose 1, T Yamamoto 1
PMCID: PMC41822  PMID: 7761428

Abstract

By screening a cDNA library constructed from aortic total RNA derived from Watanabe heritable hyperlipidemic (WHHL) rabbits by differential hybridization, we have obtained a cDNA encoding the kappa light chain of immunoglobulin. Northern blot analysis of total RNA prepared from aortas of WHHL and normal rabbits of various ages revealed that this light-chain mRNA accumulates gradually with age in aortas in WHHL rabbits. Northern blotting and in situ hybridization with an antisense oligonucleotide specific to rabbit immunoglobulin gamma heavy-chain mRNA also detected accumulation of this heavy-chain mRNA in advanced lesions of WHHL rabbit aortas. Moreover, immunohistochemical and electron microscopic analyses demonstrated the presence of plasma cells in the atherosclerotic lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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