Figure 3.

Hydrophobic residues in the S100A10 dimer (represented as sticks C: green, N: blue, O: red, S: yellow, H: white) creating binding areas H1 (a) and H2 (b) for the substituted phenyl ring (a) and pendant furfuryl ring (b) of compounds 1a, 35 and 36. Compounds are coloured as in Figure 2b. Figure created in Pymol (DeLano).