Table 2.
Compd | n | R2 | R1 | pIC50 ± SE | IC50 (μM) |
---|---|---|---|---|---|
35 | 1 | 3,4-Dimethyl | Furfuryl | 5.02 ± 0.04 | 10 |
41 | 1 | 3,4-Dimethyl | Allyl | 4.56 ± 0.03 | 27 |
42 | 1 | 3,4-Dimethyl | 3-OMe-propyl | 4.49 ± 0.04 | 32 |
43 | 1 | 3,4-Dimethyl | 4-OMe-phenyl | 4.29 ± 0.09 | 52 |
44 | 1 | 3,4-Dimethyl | 4-Cl-phenyl | 4.23 ± 0.08 | 59 |
45 | 2 | 3,4-Dimethyl | Furfuryl | 4.62 ± 0.03 | 24 |
36 | 1 | 4-iPr | Furfuryl | 5.35 ± 0.04 | 4 |
46 | 1 | 4-iPr | Allyl | 5.01 ± 0.03 | 10 |
47 | 1 | 4-iPr | 3-OMe-propyl | 5.13 ± 0.04 | 7 |
48 | 1 | 4-iPr | 4-OMe-phenyl | 4.82 ± 0.02 | 15 |
49 | 1 | 4-iPr | 4-Cl-phenyl | 4.58 ± 0.04 | 27 |
37 | 1 | 4-CF3 | Furfuryl | 4.55 ± 0.07 | 28 |
50 | 1 | 4-CF3 | Allyl | 5.08 ± 0.04 | 8 |
51 | 1 | 4-CF3 | 3-OMe-propyl | 5.02 ± 0.04 | 10 |
52 | 1 | 4-CF3 | 4-OMe-phenyl | 5.35 ± 0.04 | 4 |
53 | 1 | 4-CF3 | 4-Cl-phenyl | 5.07 ± 0.03 | 8 |
54 | 1 | 3,5-Di-CF3 | 4-OMe-phenyl | 5.14 ± 0.04 | 7 |
55 | 1 | 4-Cl | 4-OMe-phenyl | 4.65 ± 0.05 | 22 |
56 | 1 | 4-MeO | 4-OMe-phenyl | 3.81 ± 0.03 | 154 |