Table 2.

SARs of 3,4,5-trisubstituted-1,2,4-triazole analogues (35–37 and 41–56). Data are based upon 12 observations

Compd	n	R2	R1	pIC50 ± SE	IC50 (μM)
35	1	3,4-Dimethyl	Furfuryl	5.02 ± 0.04	10
41	1	3,4-Dimethyl	Allyl	4.56 ± 0.03	27
42	1	3,4-Dimethyl	3-OMe-propyl	4.49 ± 0.04	32
43	1	3,4-Dimethyl	4-OMe-phenyl	4.29 ± 0.09	52
44	1	3,4-Dimethyl	4-Cl-phenyl	4.23 ± 0.08	59
45	2	3,4-Dimethyl	Furfuryl	4.62 ± 0.03	24
36	1	4-iPr	Furfuryl	5.35 ± 0.04	4
46	1	4-iPr	Allyl	5.01 ± 0.03	10
47	1	4-iPr	3-OMe-propyl	5.13 ± 0.04	7
48	1	4-iPr	4-OMe-phenyl	4.82 ± 0.02	15
49	1	4-iPr	4-Cl-phenyl	4.58 ± 0.04	27
37	1	4-CF3	Furfuryl	4.55 ± 0.07	28
50	1	4-CF3	Allyl	5.08 ± 0.04	8
51	1	4-CF3	3-OMe-propyl	5.02 ± 0.04	10
52	1	4-CF3	4-OMe-phenyl	5.35 ± 0.04	4
53	1	4-CF3	4-Cl-phenyl	5.07 ± 0.03	8
54	1	3,5-Di-CF3	4-OMe-phenyl	5.14 ± 0.04	7
55	1	4-Cl	4-OMe-phenyl	4.65 ± 0.05	22
56	1	4-MeO	4-OMe-phenyl	3.81 ± 0.03	154