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. 2014 Oct 1;22(19):5378–5391. doi: 10.1016/j.bmc.2014.07.043

Table 3.

SARs of 5-methyl-4-substituted (R2)-4H-[1,2,4]triazole analogues (62–66). Data are based upon 12 observations

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Compd n R2 R1 pIC50 ± SE IC50 (μM)
62 1 3,4-Dimethyl Furfuryl 2.32 ± 0.48 >1000
63 2 3,4-Dimethyl Furfuryl 2.95 ± 0.26 >1000
64 1 4-iPr Furfuryl 4.40 ± 0.03 40
65 1 4-iPr Allyl 3.86 ± 0.11 138
66 1 4-iPr 3-OMe-propyl 3.79 ± 0.14 164