Figure 6. Anti-proliferative effect of 4g tested against AML cell lines in liquid culture.
Panels (A–D): MTT assay determined cell viability of AML cells. 8,000 cells per well were seeded for MOLM13, MOLM14, MV4-11 and HL-60 cells in 96 well plates in quadruplicates. A series of dilutions (starting from 1.25 µm to 10 µm) of 4g were added into the wells. Cell proliferation was measured after compound 4g treatment relative to diluents controls. Results represent the mean ±SD of three independent experiments with quadruplicate wells per experiment point. ** P≤0.001; *** P≤0.0001 (Student's t-test).