Fig. 7.

Structural modelling of wild-type and S279F C. albicans CYP51 proteins with and without fluconazole docked. a Wild-type protein, with S279 located peripherally on an external β turn. The S279F mutant protein also shown has F279 incorporated within a short section of α helix preceding the long I helix. b The wild-type protein shows fluconazole in the centre (coloured by element) and the haem group to the right, and residues predicted to be within the range of contact of fluconazole are labelled. The S279F mutant protein is also shown with the S279F substitution leading to conformational changes that result in S507 being removed from interaction with fluconazole but still bordering the haem cavity