Figure 2. Restoration of DMN under mechanical ventilation.

(A). Comparison of BOLD signal between MV and SB revealed a specific increase of activation in the default-mode network associated in awake controls in introspection and self-consciousness. No significant result was observed in the opposite contrast. See Table 1 for detailed fMRI results. (B&C). Functional connectivity assessed with a hypothesis-driven approach revealed a larger correlation with precuneus activity in posterior mesial areas during MV than during SB (B), and a larger correlation between brainstem activity and a large anterior cortico-subcortical network during SB than during MV (C). This large network resembles the executive attention network.