Table 3. Baseline leukocyte subsets and plasma cytokines of patients and controls.
SA | NSTE-ACS | Controls | P-value | |
N = 30 | N = 20 | N = 37 | ||
Leukocytes (x109/L) | 7.1±2.2 | 7.7±2.3 | 5.5±1.4 | <0.001ψγ |
Neutrophils (x109/L) | 4.1±1.5 | 4.5±1.7 | 3.0±1.0 | <0.001ψγ |
Monocytes (x109/L) | 0.6±0.2 | 0.6±0.3 | 0.4±0.1 | <0.001ψγ |
Lymphocytes (x109/L) | 2.2±1.0 | 2.4±0.9 | 2.0±0.6 | NS |
CD19+ cells, % of lymphocytes | 10 (7,12) | 10 (8,15) | 10 (7,14) | NS |
CD4+ cells, % of lymphocytes | 49 (42,54) | 50 (44,54) | 39 (33,48) | 0.005ψ, 0.001γ |
CD8+ cells, % of lymphocytes | 25 (20,31) | 25 (17,31) | 23 (19,29) | NS |
NK cells, % of lymphocytes | 12 (9,18) | 12 (7,15) | 18 (11,28) | 0.023ψγ |
Neutrophil/lymphocyte ratio | 2.1 (1.4,2.4) | 2.0 (1.5,2.5) | 1.5 (1.2,1.9) | 0.012ψ, 0.027γ |
Plasma IL-6, pg/mL | 3.1 (2.0,5.7) | 4.9 (2.9,8.0) | 1.4 (1.0,2.2) | <0.001ψγ |
Plasma CRP, mg/L | 1.2 (0.3,3.2) | 3.2 (2.2,5.0) | 0.7 (0.4,1.2) | 0.023Φ, <0.001γ |
The data are presented as mean ±SD or median (25th, 75th percentile). SA = stable angina; NSTE-ACS = non-ST-elevation acute coronary syndrome; CD19+ cells, B cells; CD4+ cells, T helper cells; CD8+ cell, cytotoxic T cell; NK = Natural killer; IL = interleukin; CRP = C-reactive protein. NS = non-significant (p≥0.05). For comparisons between groups, p-values indicating significant differences are denoted by ψ (controls vs SA), γ (controls vs NSTE-ACS) and Φ (SA vs NSTE-ACS), respectively.