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. 2014 Sep 30;9(9):e108403. doi: 10.1371/journal.pone.0108403

Figure 6. Bevacizumab prevented hyperglycaemia-mediated neurite outgrowth impairment and normalized FLT-1.

Figure 6

(A) bevacizumab prevented the decrease of hyperglycaemia-mediated neurite outgrowth in neuron-SC co-cultures (n = 5) and (B) the increase of FLT-1 mRNA in neurons monocultures (n = 5). (C) Representative and (D) quantitative western blot (WB) (n = 5) showing the significant decrease of FLT-1 in hyperglycaemia-conditioned SC monocultures and the preventive effect of bevacizumab. (E) sFLT-1 decreased in the medium of all neuron and SC monocultures and co-cultures exposed to hyperglycaemia (n = 5). (F) Bevacizumab did not affect sFLT-1 level in hyperglycaemia-conditioned co-cultures (n = 3). Data are expressed as mean±SEM of independent experiments. *p<0.05 vs controls; #p<0.05 vs hyperglycaemia; ##p<0.01 vs hyperglycaemia.