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. 2014 Sep 30;9(9):e108645. doi: 10.1371/journal.pone.0108645

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© 2014 Xu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Rats were divided into sham-operated control (Con), sham-operated plus 100 mg/kg magnesium control (Mg), STZ ICV (STZ) or STZ ICV plus 100 mg/kg magnesium (STZ+Mg) groups and treated as shown in Figure 1A. The total Akt, Akt (Thr308), Akt (Ser473), total PI3K and PI3K (Tyr458/199) levels in whole hippocampus extracts were measured using Western blotting (A, C) and quantitative analysis (B, D), respectively. The p-Akt (Ser473) and p-PI3K (Tyr458/199) levels decreased significantly in ICV-STZ-treated rats, and these changes were fully restored by magnesium supplement. There was no change in total Akt, Akt (Thr308) and PI3K. Data were presented as means ± SD. *P<0.05 versus the control group, #P<0.05 versus the STZ group.