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. 2014 Sep 30;9(9):e109030. doi: 10.1371/journal.pone.0109030

Figure 1. The effect of cisplatin and voluntary wheel running on muscle mass, strength, food intake and body weight.

Figure 1

Mice (n = 16–18) were treated with 4 mg/kg cisplatin (CIS) or saline (Control) once weekly for 6 weeks. During treatment mice were assigned to running wheels in their home cages (Ex) or not. A) Body weight was recorded weekly during the intervention. *** Indicates a significant effect of time (change from baseline, P<0.001), # indicates significant different from the control group (P<0.001)(No Ex = 16, Ex = 18). B) Change in lean body mass (LBM) by DXA scanning before and after the 6 weeks intervention (No Ex = 8, Ex = 9). C) Food intake was recorded per cage with 3 mice. A significant effect of time (P<0.001), cisplatin treatment (P<0.001) and the interaction (P<0.001) between the two was observed (n = 6). D) Weight of TA muscle (No Ex = 16, Ex = 18). E) Weight of heart (No Ex = 16, Ex = 18). F) Fall score from hang test performed 3 days after last cisplatin treatment (No Ex = 8, Ex = 9). Results are presented as means ± SEM. Statistical analysis was performed by 2-way ANOVA with repeated measurements and post hoc test (A, C, D) or post hoc paired T-tests (B) with Bonferroni corrections. * P<0.05, ** P<0.01, ***P<0.001 indicates statistical significance compared to non-exercising control or as indicated by the lines except in A) or $P<0.05 compared to pre-treatment levels (B).